Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers

Inclusion Criteria: 1. Aged between 21 and 70 years old 2. Male or female willing to comply with the study visits and procedures 3. Willing and able to provide written informed consent Exclusion Criteria: 1. Women who are currently pregnant or breastfeeding 2. Body weight 50kg or below 3. HLA-B\*5801 allele positive 4. Clinical evidence (symptoms and/or signs) suggestive of active TB 5. Previous hypersensitivity, intolerance or allergy to pyrazinamide or allopurinol 6. Current use of any drugs or medication known to have an interaction with pyrazinamide or allopurinol, or known to have anti-TB activity 7. Evidence of renal or hepatic dysfunction or any clinically significant deviation from normal during screening including laboratory determinations 8. Known hepatic disease (including chronic hepatitis), recent hepatitis (within last 6 months) or alcohol abuse 9. Known hyperuricaemia or evidence of hyperuricaemia at screening 10. History or current episode of gout 11. Any other significant condition that would, in the opinion of the investigator, compromise the volunteer's safety or outcome in the trial 12. Current participation in other clinical intervention trial or research protocol