This trial will compare the efficacy and tolerability of 10 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered once daily over 30 days, in patients with a diagnosis of bulimia or anorexia nervosa binge-purge subtype. The trial will include structural and functional MRI, and behavioral measures obtained before, during, and after treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
90
10 Hz active stimulation, once daily
1 Hz active stimulation, once daily
Sham stimulation, once daily
Toronto Western Hospital
Toronto, Ontario, Canada
Weekly Binge/Purge Frequency on Eating Disorder Examination (EDE)
Outcome measured by a change in weekly binge and purge episodes from baseline to 2 weeks post-treatment. A 50% improvement in the score is considered a response to rTMS. A final score of 0 weekly binges and 0 weekly vomits is categorized as remission.
Time frame: Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment
Eating Disorder Inventory-3
Time frame: Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment
Eating Disorder Examination Questionnaire (EDE-Q)
Time frame: Baseline, after each week of treatment, and 1, 4, 12, and 24 weeks post-treatment
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