This cross-over intervention study aims to investigate the effect of two doses of thylakoids to an oral glucose tolerance test (OGTT) on glucose and insulin homeostasis as well as appetite regulating hormones in healthy volunteers.
A minimum of twenty healthy volunteers are recruited to participate in an OGTT at three different occasions separated by one week. At two of the occasions a green leaf extract, thylakoids, is added to a glucose solution; 5 gram or 10 gram in randomized order. The third occasion, without added thylakoids, serve as control. Blood samples are taken fasting and 15, 30, 45, 60, 90, 120 and 180 minutes after the glucose load. Blood samples are analysed for p-glucose, p-insulin, p-C-peptide, p-ghrelin, p-CCK and p-GLP-1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
21
75 g pure glucose + 5 g chloroplast membranes from spinach leaves in a dried powder.
75 g pure glucose + 10 g chloroplast membranes from spinach leaves in a dried powder.
75 g pure glucose.
Insulin sensitivity
Measurement of p-glucose, p-insulin and p-C-peptide in repeated blood sampling during three hours after an OGTT.
Time frame: 180 minutes, repeated at three occasions
p-GLP-1
Repeated blood sampling during three hours after an OGTT.
Time frame: 180 minutes, repeated at three occasions
p-ghrelin
Repeated blood sampling during three hours after an OGTT.
Time frame: 180 minutes, repeated at three occasions
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