Vitamin A Equivalence of the Provitamin A in Biofortified Bananas

N/ACompletedNCT02702622

Iowa State University

Overview

The objective will be to quantify the vitamin A equivalence of the provitamin A in transgenic biofortified bananas.

Study Type

INTERVENTIONAL

Conditions

Vitamin A Deficiency

Interventions

Provitamin A-biofortified transgenic bananasOTHER

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * General good health as determined by interview, blood biochemistry profile, and complete blood count * Antecubital veins amenable to blood collection Exclusion Criteria: * Adverse reactions to blood sample collection * History of anemia or excessive bleeding * Cigarette smoking, frequent alcohol consumption * Use of vitamin/mineral supplements * Food allergies * Lactose intolerance * Abnormal thyroid status * Chronic disease, lipid malabsorption or gastrointestinal disorders * Hyper- or hypolipidemia * Body mass index (BMI) \> 28 * History of eating disorder or restrained eating * Current or planned pregnancy; menstrual cycle irregularities or abnormalities * Use of hormonal contraceptives (affects chylomicron clearance); use of medications that may affect lipid absorption or transport

Outcomes

Primary Outcomes

Area under the curve for retinyl ester in the plasma triacylglycerol-rich lipoprotein fraction

Time frame: 0 - 9.5 hours postprandially

Data from ClinicalTrials.gov

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