First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders

Key inclusion Criteria: * Signed informed consent * Healthy on the basis of physical examination,12-lead electrocardiogram and laboratory tests * Males and females of non-childbearing potential, aged between 18 and 60 years (all inclusive) * Women must have a negative serum pregnancy test at Screening and a negative urine pregnancy test predose on Day -1 * Body mass index (BMI) between 18.0 and 29.9 kg/m2 (inclusive) * Systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse rate (PR) between 90-140 mmHg, 50-90 mmHg and 50-90 bpm (all inclusive), respectively Key exclusion Criteria: * History or clinical evidence of any disease and/or existence of any surgical or medical condition which might interfere with the absorption, distribution, metabolism or excretion of the study treatment * Previous history of fainting, collapse, syncope, orthostatic hypotension, or vasovagal reactions * Any circumstances or conditions, which, in the opinion of the Investigator, may affect full participation in the study or compliance with the protocol