Photo-induction as a Means to Improve Cisplatin Delivery to Pleural Malignancies

Inclusion criteria * Stage IV breast, ovarian, gastric, colorectal, germ cell, lung, bladder, sarcoma or head and neck carcinoma requiring systemic chemotherapy OR alternatively * Stage I/II malignant pleural mesothelioma OR alternatively * Stage III/IV mesothelioma requiring systemic chemotherapy OR alternatively * Stage IVa thymic malignancies AND * Cytologically proven malignant pleural effusion requiring VATS pleurodesis * PS 0-1 * Age 18-80 * Written informed content * Life expectancy \>3 months * Laboratory Requirements - within 28 days prior to enrollment: * Haematology: * absolute granulocytes ≥1× 109/L * platelets ≥100 × 109/L * leukocytes ≥3 × 109 * Biochemistry: * Bilirubin ≤3 × upper limit of normal (\<5x if liver metastasis present) * AST(SGOT) ≤2.5 × upper limit of normal (\<5x if liver metastasis present) * Creatinine clearance ≥50 mL/min according to Cockroft and Gault * No major cardio-pulmonary co-morbidity precluding a surgical approach according to local standards * Enrollment decision at the institutional multidisciplinary tumor board * Patient must be willing to use effective methods of contraception. Female patients must be postmenopausal, surgically sterile, or they must agree to use a physical barrier method of contraception in addition to either an intrauterine device or hormonal contraception until at least of 3 months after the study treatment. Male patients must agree to use a barrier method (condom) for 3 months after study treatment. Exclusion criteria * Grade \>2 peripheral neuropathy * Any concurrent anticancer systemic therapy within 14 days before the study intervention * Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study e.g. Known or suspected allergy to the investigational agent or any agent given in association with this trial. Clinically serious infections requiring systemic antibiotic (e.g antiviral, antimicrobial, antifungal) therapy. * Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results * Severe interstitial pneumonia or pulmonary fibrosis * Chronic corticosteroid use at equivalent dose of \>30mg/d methylprednisolone * Pregnancy or breast-feeding * Porphyria * Severe liver insufficiency