REPAIR - transcatheteR rEPair of mitrAl Insufficiency With caRdioband System

Inclusion Criteria: 1. Age ≥18 years 2. Severe (3+ to 4+) secondary Mitral Regurgitation 3. Symptomatic heart failure (NYHA Class III-IVa) despite guideline directed medical therapy including CRT if indicated 4. The Local Site Heart Team concur that surgery will not be offered as a treatment option and that medical therapy is the intended therapy. 5. Transfemoral access and transseptal deployment of the Cardioband is determined to be feasible 6. Subject is willing and able to provide informed consent and follow protocol Exclusion Criteria: 1. EF \< 20% 2. LVEDD ≥ 70 mm 3. Heavily calcified annulus or leaflets 4. Significant CAD requiring revascularization 5. Active bacterial endocarditis 6. Any percutaneous coronary, carotid, endovascular intervention or carotid surgery within 30 days or any coronary or endovascular surgery within 3 months 7. Renal insufficiency requiring dialysis 8. Life expectancy of less than twelve months 9. Subject is participating in concomitant research studies of investigational products that have not reached their primary endpoint 10. Pulmonary hypertension ≥ 70mmHg at rest 11. Mitral valve anatomy which may preclude proper device treatment 12. Right-sided congestive heart failure with echocardiographic evidence of severe right ventricular dysfunction and/or severe tricuspid regurgitation 13. Severe liver disease 14. Patient is pregnant or lactating 15. Hypersensitivity to Nickel or Chromium 16. Clinically significant bleeding diathesis or coagulopathy 17. History of mitral valve repair 18. TIA or CVA within 3 months