Subthalamic Nucleus Stimulation Effect on Gait Symmetry and Freezing of Gait

University Hospital, Grenoble12 enrolled

Overview

Impact of unilateral modulation of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease

Unilateral modulation of subthalamic stimulation and its impact on freezing of gait in Parkinson's disease will be studied. In a cross-over, doubleblind, randomized study, a 30% reduction of stimulation intensity of the less impacted side will be compared with chronic treatment with regard to frequency and duration of freezing of gait episodes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Parkinson Disease

Interventions

Unilateral reduction of stimulationPROCEDURE

30% unilateral reduction of Subthalamic nucleus stimulation

Chronic Subthalamic nucleus stimulationPROCEDURE

This arm is the reference, with the best stimulation parameters

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients affiliated to social security Patient with idiopathic parkinson's disease, with deep brain stimulation since at least one year Freezing of gait Able to give inform consent Exclusion Criteria: Patient under guardianship, legal guardianship Psychosis Severe depression Severe cognitive troubles (Mattis \< 130) Other neurologic or medical pathology interfering with gait

Locations (1)

CHU Grenoble

Grenoble, France

Outcomes

Primary Outcomes

improvement of Freezing of gait

the improvement will be measure with a composite score of items 12 + 13 on UPDRS II and items 10+11 on UPDRS III,

Time frame: 1 month after new stimulation parameters

Data from ClinicalTrials.gov

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