Study Of Weight-Based Versus Standard Dose Enoxaparin Thromboprophylaxis In High-Risk Hospitalized Cancer Patients

Inclusion Criteria: * Participants must have histologically or cytologically confirmed diagnosis of solid tumor malignancy, lymphoma or multiple myeloma. * Cancer diagnosis or received treatment (chemotherapy or radiotherapy) for malignancy within the previous 6 months * One or more Padua-based risk factor: * History of previous venous thromboembolic event (excluding superficial vein thrombosis) * Reduced mobility (ECOG performance status 3 or 4, see Appendix A) * Established hereditary thrombophilia (e.g. Factor V Leiden, G20210 prothrombin mutation, protein C or S deficiency, antithrombin deficiency). * Recent surgery within the last 30 days * Age ≥ 70 years * Congestive heart failure (NYHA class III or IV) * Complicated respiratory insufficiency (defined as an increased requirement for supplementary oxygen of at least 2L) * Acute myocardial infarction or ischemic stroke * Obesity (BMI ≥ 30) * Receiving hormonal agents (e.g. tamoxifen, estrogen, testosterone) * Acute infection (i.e. requiring antimicrobial therapy) * Age ≥ 18 years * Life expectancy of greater than 30 days * Platelet count ≥ 100,000/mcL * Creatinine \< 1.5 mg/dL or estimated creatinine clearance ≥ 50 mL/min/1.73 m2 * Ability to understand and the willingness to sign a written informed consent document * Weight between 50kg to 130 kg. Exclusion Criteria: * History of allergic reactions attributed to heparin or low molecular weight heparin * Active bleeding or otherwise considered high risk for hemorrhage (e.g. known acute gastrointestinal ulcer) * Any history of significant hemorrhage (requiring hospitalization or transfusion) within the last 6 months (excluding hemorrhage during operative procedure). * History of heparin induced Thrombocytopenia * Presence of coagulopathy (PT or PTT\> 1.2 x upper limit of normal) * Known diagnosis of disseminated intravascular coagulation * Currently receiving therapeutic anticoagulant therapy or dual antiplatelet therapy (eg. aspirin and clopidogrel) * Uncontrolled arterial hypertension (systolic blood pressure \> 200mmHg, diastolic \>110mmHg) * Active peptic ulcer disease * Bacterial Endocardititis * Received any type of Pharmacologic Thromboprophylaxis (e.g. low molecular weight heparin or heparin) for \>48 hours during current hospitalization * Known brain metastases