Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients

Gangnam Severance Hospital3 enrolled

Overview

This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.

Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Insulin Resistance Inflammation Delirium

Interventions

Allocated to Carbohydrated groupDIETARY_SUPPLEMENT

Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.

Allocated to Placebo groupDIETARY_SUPPLEMENT

Patients received 400 mL of oral flavored water (Placebo) 12 hours before anesthesia and 400 mL 2 hours before

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing total hip replacement or total knee replacement surgery Exclusion Criteria: * Diabetes * Dementia * Gastro-esophageal reflux * Upper gastrointestinal motility disorder * Inflammatory bowel disease * Intraperitoneal malignancy history * Inability to perform cognitive function test

Outcomes

Primary Outcomes

serum S-100β level

Time frame: Postoperative 1 hr

Data from ClinicalTrials.gov

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