The purpose of this study is to determine whether early neuromuscular electrical stimulation is effective in the prevention of neuromuscular weakness in critical ill patients.
Randomized, controlled study of early electrical neurostimulation (vs sham) in critically ill patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
102
NEMS is delivered bilaterally to the quadriceps femoris muscle using a portable battery-powered stimulator (Rehab 400, Cefar Compex, France). The electrodes are placed on the motor points of vastus medialis and vastus lateralis muscles. Electrical stimuli of 45Hz (pulse width: 380 µseconds; 6 seconds on with 1.5 second rise time; and 0.75 seconds fall time.; 5 seconds off). The current is adjusted to ensure maximum tolerable muscle contraction The protocol is applied twice daily for 25 minutes, five days a week.
No electrostimulation
Insitut Mutualiste Montsouris
Paris, France
RECRUITINGMedical resuscitation council (MRC) score
Time frame: up to 25 months. From date of randomization to the date of ICU discharge
Total duration of mechanical ventilation (days)
Time frame: up to 25 months. From date of randomization to the date of ICU discharge
Length of ICU stay and hospital stay.
Time frame: up to 25 months. From date of randomization to the date of ICU discharge or hospital discharge
Type of hospital discharge
(alive/deceased/rehabilitation/home...)
Time frame: up to 25 months. From date of randomization to the date of hospital discharge
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