Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia

Nanjing Maternity and Child Health Care Hospital300 enrolled

Overview

Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Labor Analgesia

Interventions

β2AR polymorphismGENETIC

Eligibility

Sex: FEMALE

Outcomes

Primary Outcomes

total labor process

time from the regular uterus contractions until completed childbirth, assessed up to about 24h

Time frame: up to about 24h

duration of the first stage

time from the regular uterus contractions to full cervix dilation,assessed up to about 20h

Time frame: up to about 20h

duration of the second stage

time from full cervix dilation to the complete childbirth, assessed up to about 2h

Time frame: up to about 2h

Maternal visual analogue scale

At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)

Time frame: At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)

Secondary Outcomes

method of delivery

At time of placental delivery

Time frame: At time of placental delivery

Maternal modified Bromage scale

At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)

Time frame: At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)

Rescue boluses, n of rescue boluses, and the consumption of the ropivacaine/sufentanil mixture

At two hours postpartum

Time frame: At two hours postpartum

Maternal satisfaction with analgesia

At two hours postpartum

Time frame: At two hours postpartum

Use of oxytocin after analgesia

At twenty-four hours postpartum

Time frame: At twenty-four hours postpartum

Neonatal Apgar scale

At the first and fifth minutes after baby was born

Time frame: At the first and fifth minutes after baby was born

Maximal oxytocin dose

At twenty-four hours postpartum

Time frame: At twenty-four hours postpartum

Maternal heart rate, respiratory rate, and blood pressure

At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours)

Time frame: At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours)

Neonatal weight

At delivery

Time frame: At delivery