Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura.

University Hospital, Toulouse46 enrolled

Overview

Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls. Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method. MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Migraine With Aura

Interventions

Magnetic resonance imagingOTHER

Patients and controls will first be studied with MRI. The total duration of MRI is about 60mn. These technic is not invasive.

Transcranial DopplerOTHER

Patients and controls will first be studied with TCD. The total duration of TCD is about 60mn. These technic is not invasive.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Migraine with aura patients : fulfilling the International Classification of Headache Disorders-3 beta criteria of MA * Control group : Gender- and age-matched subjects without history of migraine with or without aura or any other headache Exclusion Criteria: * History of illness or injury of central or peripherical nervous system * Previous history of a disease potentially impairing cerebral autoregulation (diabetes, sleep apnea syndrome, uncontrolled hypertension, cardiac arrhythmia, hearth failure, carotid stenosis) * Contraindications related to MRI * Absence of temporal acoustic window * Pregnancy

Locations (1)

CHU Toulouse

Toulouse, France

Outcomes

Primary Outcomes

Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls.

Resonance magnetic imaging use voxel base morphometry and Transcranial doppler use the coefficient mx calculation.

Time frame: 30 days after the pre-inclusion visit

Secondary Outcomes

Comparison of brainstem grey matter density between migraine with aura patients and controls with magnetic resonance imaging

Comparison will be done with software using voxel based morphometry (VBM) function in addition of imaging with resonance magnetic imaging.