Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
1-month supplementation of 30 g MCT oil (60% C10 + 40% C8)/day
1-month supplementation of 30 g MCT oil (100% C8)/day (1-month of C8 MCT oïl)
Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)
Sherbrooke, Quebec, Canada
Quantification of brain glucose uptake
Brain glucose uptake (umol/100g/min) using 18-FDG PET scan
Time frame: 1-month
Quantification of brain acetoacetate uptake
Brain acetoacetate uptake (umol/100g/min) using 11C-AcAc PET scan
Time frame: 1-month
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