Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human

Phase 2CompletedNCT02709525

Federal University of Minas Gerais16 enrolled

Overview

The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Alveolar Bone Loss

Interventions

hyaluronic acidDRUG

PlaceboOTHER

Eligibility

Sex: ALLMin age: 14 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Orthodontic need for bilateral extraction of lower first premolars Exclusion Criteria: * Alcoholism, smoking, drug use and abuse of drugs; Systemic diseases: uncontrolled diabetes, blood dyscrasias, kidney or heart failure and osteoporosis; clinical or radiographic signs of pathological processes in the bone;

Outcomes

Primary Outcomes

Percentage of bone formation

During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation

Time frame: 30 days after extraction and treatment application

Fractal dimension

During the postoperative interval of 30 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image.

Time frame: 30 days after extraction and treatment application

Dimensional Alveolar changes

To determine whether treatment could prevent loss of buccolingual thickness, was compared bone loss of 90 to 30 days between the treated and control groups.

Time frame: 30 to 90 days after extraction and treatment application

Percentage of bone formation

During the postoperative interval of 90 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. Using the KS300 software, the gray intensity was measured in each image and the results were expressed as mean percentage of bone formation

Time frame: 90 days after extraction and treatment application

Fractal dimension

During the postoperative interval of 90 days, the patients underwent cone beam computed tomography (CBCT). Five central transverse scan images were captured from each socket. The pattern of the alveolar trabecular bone was also evaluated through the fractal dimension in each image.

Time frame: 90 days after extraction and treatment application

Data from ClinicalTrials.gov

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