The loss of motivation has emerged as a critical symptom in schizophrenia that is consistently linked to functional disability for affected individuals. Despite advances in treatment, there have not emerged any effective treatments for this loss of motivation, which ultimately hinders our ability to promote recovery for individuals with schizophrenia. To address this critical unmet therapeutic need, this study aims to investigate a novel computerized motivation rehabilitation program using virtual reality to treat motivation loss in schizophrenia.
Motivational deficits have emerged as a critical determinant of functional disability in schizophrenia (SZ). Despite significant advances in our understanding and treatment of the illness, effective therapeutic strategies for motivational deficits have remained elusive. This has ultimately hindered our ability to promote recovery for individuals with SZ so that they can return to their premorbid level of functioning. An emerging therapeutic approach in SZ has utilized computerized remediation strategies, with recent efforts focused on cognitive deficits. To date, however, such a therapeutic strategy has not been developed for the critical motivational deficits in SZ. In light of the detrimental functional consequences of motivational deficits in SZ, there is a clear need for effective therapeutic strategies for the treatment of these motivational deficits experienced by affected individuals. To address this unmet therapeutic need, this pilot therapeutic trial will investigate the efficacy of a novel virtual reality-based motivation rehabilitation program in schizophrenia.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Computerized treatment with a virtual reality-based motivation training program, administered for 1 hour per week for 8 weeks.
Centre for Addiction and Mental Health
Toronto, Ontario, Canada
Apathy Evaluation Scale (AES)
Time frame: 9 weeks
Scale for the Assessment of Negative Symptoms (SANS)
Time frame: 9 weeks
Quality of Life Scale (QLS)
Time frame: 9 weeks
Scale for the Assessment of Positive Symptoms (SAPS)
Time frame: 9 weeks
Brief Assessment of Cognition in Schizophrenia (BACS)
Time frame: 9 weeks
Calgary Depression Scale for Schizophrenia (CDSS)
Time frame: 9 weeks
Simulator Sickness Questionnaire (SSQ)
Time frame: 9 weeks
Functional Brain Imaging
Change in regional brain activity measured with functional MRI
Time frame: 9 weeks
Structural Brain Imaging
Changes in brain structure (e.g., white matter tract integrity) measure with structural MRI
Time frame: 9 weeks
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