Safety and Feasibility of Electrochemotherapy in Unresectable Colorectal Adenocarninoma Liver Metastases

Inclusion Criteria: * Male or female patients \> 18 years of age * Histological confirmed colorectal adenocarcinoma * Histological or clinically confirmed metastatic colorectal adenocarcinoma lesions (liver lesions only are considered as metastatic disease) and not resecable. * A single liver lesion may not exceed 3 cm * Liver lesions must not have a depth greater than 2 cm from hepatic surface (Glisson Capsule) (measured clinically if possible otherwise on the basis of CT/ultrasound examination) * A life expectancy of at least 6 months. * Patients with a ECOG performance status \< 2 * Signed Informed Consent * Patient must be mentally capable of understanding the information given. * Patient must give informed consent. Exclusion Criteria: * Age less than 18 years. * Patient pregnant or lactating (no contraceptive method is contraindicated, a pregnancy test will be administered to all women of childbearing age) * Life-threatening infection and/or heart failure and/or liver failure and/or other severe systemic pathologies that preclude laparotomy * Strumental analysis confirmed ascites. * Impaired kidney function. * Significant reduction in respiratory function. * Allergic reaction to bleomycin. * Coagulation disturbances * Patients with exclusion criteria for diagnostic MRI 3Tesla (with pace-makers and all those metal devices that are not compatible with 3T).