Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Istanbul University90 enrolled

Overview

This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Pituitary Adenoma

Interventions

SevofluraneDRUG

1-1.5 MAC, inhalation route, during operation

DesfluraneDRUG

1-1.5 MAC, inhalation route, during operation

PropofolDRUG

6-10 mg/kg/h, iv infusion, during operation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) score I-II patients Exclusion Criteria: * Significant cardiopulmonary disease, * Diagnosed obstructive or restrictive pulmonary disease, * Patients with chest wall deformities, liver or kidney failure, * Postoperative lack of cooperation

Locations (1)

Istanbul University Cerrahpasa Medical Faculty Neurosurgery Department

Istanbul, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

Change from baseline FEV1%predicted (no unit)

FEV1 is measured with spirolab III colour liquid-crystal-display medical spirometer. FEV1%predicted is calculated with age, sex, height and weight input by the same equipment.

Time frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour

Secondary Outcomes

Change from baseline FVC%predicted (no unit)

FVC is measured with spirolab III colour liquid-crystal-display medical spirometer. FVC%predicted is calculated with age, sex, height and weight input by the same equipment.

Time frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour

Change from baseline FEV1/FVC ratio (no units)

FEV1/FVC ratio is calculated by spirolab III colour liquid-crystal-display medical spirometer based on age, sex, height and weight.

Time frame: Preoperative baseline, postoperative 1st hour and postoperative 24th hour

Change from baseline PaO2 (mmHg)

PaO2 is a component of arterial blood gas analysis done with Cobas B221.

Time frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour

Change from baseline PaCO2 (mmHg)

PaCO2 is a component of arterial blood gas analysis done with Cobas B221.

Time frame: Preoperative baseline, during the 1st hour of the operation, during the last hour of the operation, postoperative 1st hour and postoperative 24th hour

Change from baseline pH

pH is a component of arterial blood gas analysis done with Cobas B221

Central Contacts

Abdulvahap Oguz, MD

CONTACT

00905444461924 avahapoguz@gmail.com

Data from ClinicalTrials.gov

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