The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polyphenols have only considered a fraction of polyphenols, i.e., extractable polyphenols. As a consequence, an important amount of dietary polyphenols, the so-called non-extractable polyphenols are ignored. In contrast, the effect of both extractable and non-extractable polyphenols will be considered in this study. Furthermore, the effect of both polyphenols as present in the food matrix and metabolites derived from microbial fermentation will be evaluated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Oral Glucose Tolerance Test
Oral Glucose Tolerance Test right after taking the mixture of grape and pomegranate polyphenols
Oral Glucose Tolerance Test ten hours after taking the mixture of grape and pomegranate polyphenols
Institute of Food Science, Technology and Nutrition, National Research Council (ICTAN-CSIC)
Madrid, Madrid, Spain
Postprandial glucose
Changes in blood glucose response in treatments B and C will be compared with the baseline results obtained in treatment A. This will be evaluated by area under the curve (AUC) 0-120 min after an Oral Glucose Tolerance Test (OGTT)
Time frame: 0-120 min.
Postprandial insulin
Changes in blood insulin response in treatments B and C will be compared with the baseline results obtained in treatment A. This will be evaluated by area under the curve (AUC) 0-120 min after an Oral Glucose Tolerance Test (OGTT)
Time frame: 0-120 min.
Postprandial uric acid
Changes in blood uric acid response in treatments B and C will be compared with the baseline results obtained in treatment A. This will be evaluated by area under the curve (AUC) 0-120 min after an Oral Glucose Tolerance Test (OGTT)
Time frame: 0-120 min.
Polyphenol metabolites
Urinary polyphenol metabolites will be determined in samples collected in the period 0-180 min. of each intervention.
Time frame: 0-180 min.
Urinary uric acid
Urinary uric acid will be determined in samples collected in the period 0-180 min. of each intervention.
Time frame: 0-180 min.
Satiety
A satiety test, including 10 items, will be provided at different time points during the period 0-120 min. of each intervention.
Time frame: 120 min.
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