A Study of Apatinib Mesylate (YN968D1) 1,000mg in Gastric Cancer Patient Failed to Standard Treatment

Inclusion Criteria: * 19 years of age or older * Subjects with histologically confirmed unresectable locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction * Failure or noncompliance of existing standard treatment without alternative treatment * Measurable disease measured by proper image examination defined by RECIST 1.1 * Life expectancy ≥ 3 months * Subject must be suitable for oral administration of study medication * Subject who can submit a written consent form before participating in the test * Adequate bone marrow, renal, and liver function * Electrocorticography(ECOG) performance status ≤ 2 * Ability and willingness to comply with the study protocol for the duration of the study Exclusion Criteria: * Pregnant or lactating women * Therapy with clinically significant systemic anticoagulant or antithrombotic agents within 7 days prior to first scheduled dose of YN968D1 * Hemoptysis within 3 months prior to first scheduled dose of YN968D1 * Cytotoxic chemotherapy, immunotherapy, radiotherapy or other targeted therapies within 4 weeks (6 weeks in cases of mitomycin C, nitrosourea, lomustine) prior to first scheduled dose of YN968D1 * Surgery or biopsy within 28 days prior to first scheduled dose of YN968D1 * Minor surgery within 7 days prior to first scheduled dose of YN968D1 * Patients who have experience using YN968D1 before * Concomitant treatment with strong inhibitors or inducers of CYP3A4, CYP2C9 and CYP2C19 * Known history of human immunodeficiency virus infection (HIV) * Medical history of other cancers (including blood cancer) in the 5 years * Radiology therapy to target lesion within 28 days, or diagnosis of other cancer within 14 days prior to first scheduled dose of YN968D1 * History of bleeding diathesis or bleeding within 14 days prior to enrollment * Medical history of clinically significant thrombosis (bleeding or clotting disorder) within the past 3-months * History of non-malignant GI bleeding, gastric stress ulcerations, or peptic ulcer disease within the past 3-months * History of idiopathic or hereditary angioedema, sickle cell or any hemolytic anemia * History of uncontrolled hypertension that in the opinion of the investigator * Complete Left bundle branch block (LBBB) or bifascicular (RBBB and left anterior or posterior hemi-block) * Clinically significant S-T segment or T wave abnormality * Abnormal atrial fibrillation * History of ECOG or left ventricular ejection fraction (LVEF) abnormality during last 3 months in the opinion of the investigator * Myocardial infarction or unstable angina pectoris within 6 months prior to starting study medication * Congestive heart failure (New York Heart Association class III-IV) * History of other significant cardiovascular disease or vascular disease within the last 6 months * History of clinically significant glomerulonephritis, biopsy proven tubulointerstitial nephritis, crystal nephropathy, or other renal insufficiencies Treatment with an investigational agent within the longest time frame of either 5 half-lives or 30 days of initiating study drug * Half-life of other investigator drug is not passed over fivefold or 30 days prior to clinical trial * Known recreational substance use or psychiatric illness that, in the opinion of the Investigator, may affect compliance with scheduled visits * Known hypersensitivity to YN968D1 or components of the formulation