A Phase IIA FF/VI Study to Measure FeNO in Asthmatic Patients.

Inclusion Criteria: * Age of subject: Between 18 and 65 years of age inclusive, at the time of signing the informed consent. * A doctor diagnosis of asthma for at least 6 months prior to the start of the study. * Severity of disease: A screening pre-bronchodilator forced expiratory volume in one second (FEV1) \>=60% of predicted values, which will be based upon NHANES III * Reversibility of disease: Demonstrated presence of reversible airway disease at screening (repeat testing of eligibility can be undertaken following the screening visit up to Day -7) OR The presence of reversible airways disease can have been demonstrated historically within 6 months of the screening visit. Reversible airway disease is defined as increase in FEV1 of \>=12% over baseline and an absolute change of \>=200 mL within 30 minutes following 4 inhalations of albuterol/salbutamol inhalation aerosol/spacer (or equivalent nebulised treatment with albuterol/salbutamol solution). * Current Therapy: Short-acting beta2-agonists (SABA) prescribed for at least 12 weeks prior to screening. No inhaled corticosteroids (ICS), long-actint beta2-receptor agonist (LABA), long acting muscarinic anatagonist (LAMA), leukotriene receptor antagonist (LTRA) therapy for three months prior to the start of the study. * Non-smoker or ex-smoker (no smoking in previous 12 weeks, ≤10 pack years). * Screening and Day -7 AM fraction of inhaled nitric oxide (FeNO) values \> 40ppb. Both screening and Day -7 AM FeNO values for treatment Period 1 need to be \> 40ppb for the subject to be eligible. * Bodyweight and BMI: Bodyweight \>=50 kg and body mass index (BMI) within the range 18.0 40.0 kg/m2 (inclusive) * Male OR Female: * Females: A female subject is eligible to participate if she is not pregnant (as confirmed by a negative urine human chorionic gonadotrophin \[hCG\[ test), not lactating, and at least one of the following conditions applies: Non-reproductive potential defined as: * Pre-menopausal females reporting one of the following: Tubal ligation Hysteroscopic tubal occlusion procedure with follow-up confirmation of bilateral tubal occlusion Hysterectomy Bilateral Oophorectomy * Postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone \[FSH\] and estradiol levels consistent with menopause \[refer to laboratory reference ranges for confirmatory levels\]). Females on hormone replacement therapy (HRT) and whose menopausal status is in doubt will be required to use one of the highly effective contraception methods if they wish to continue their HRT during the study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior to study enrolment. * Reproductive potential and agrees to follow one of the options listed in the Modified List of Highly Effective Methods for Avoiding Pregnancy in Females of Reproductive Potential (FRP) from 30 days prior to the first dose of study medication and until after the last dose of study medication and completion of the follow-up visit * The investigator is responsible for ensuring that subjects understand how to properly use these methods of contraception. * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the consent form and in this protocol. Exclusion Criteria: * A history of life-threatening asthma, which is defined as an asthma episode that required intubation and/or was associated with hypercapnia, respiratory arrest or hypoxic seizures within the last 5 years * Other significant pulmonary diseases to include (but not limited to): pneumonia, pneumothorax, atelectasis, pulmonary fibrotic disease, bronchopulmonary dysplasia, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, or other respiratory abnormalities other than asthma. * Respiratory Infection: Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of screening that led to a change in asthma management OR in the opinion of the Investigator, is expected to affect the subject's asthma status OR the subject's ability to participate in the study. However, subjects can be rescreened to allow for an adequate time period (of at least 4 weeks) between resolution of the infection and the date of randomisation. * Asthma Exacerbation: Any asthma exacerbation requiring oral corticosteroids within 12 weeks of screening or that resulted in overnight hospitalization requiring additional treatment for asthma within 6 months prior to screening. * Pre-defined concomitant medications and restrictions of nitrate-rich foods * Tobacco Use: Current smokers or a smoking history of \>=10 pack years. A subject may not have used any inhaled tobacco products in 12 weeks preceding the screening visit. * Previous Participation: Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Other concurrent Diseases/Abnormalities: A subject has any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the study results if the condition/disease exacerbated during the study. * The list of additional excluded conditions/diseases includes, but is not limited to the following: * Congestive heart failure-Known aortic aneurysm * Clinically significant coronary heart disease-Clinically significant cardiac arrhythmia * Stroke within 3 months of Visit 1-Uncontrolled hypertension * Recent or poorly controlled peptic ulcer-Haematologic, hepatic, or renal disease * Immunologic compromise-Current malignancy * Tuberculosis (current or untreated)-Cushing's disease * Addison's disease-Uncontrolled diabetes mellitus * Liver cirrhosis-Systemic Lupus Erythematosus * Uncontrolled thyroid disorder-Recent history of drug or alcohol abuse * Oropharyngeal examination: A subject will not be eligible if he/she has clinical visual evidence of oral candidiasis at screening. * Pregnancy and Lactating Females: * Pregnant females as determined by positive serum hCG test at screening or by positive urine hCG test prior to dosing. * Lactating females * Allergies: * Milk Protein Allergy: History of severe milk protein allergy. * Drug Allergy: Any adverse reaction including immediate or delayed hypersensitivity to any beta2-agonist, sympathomimetic drug, or any intranasal, inhaled, or systemic corticosteroid therapy. Known or suspected sensitivity to the constituents of the Dry Powder Inhaler (DPI) (i.e., lactose or magnesium stearate). * Historical Allergy: History of drug or other allergy that, in the opinion of investigator or GSK Medical Monitor, contraindicates their participation