Integrative Medicine of IgA Nephropathy

Inclusion Criteria: 1. The primary IgAN was confirmed by renal biopsy and clinical examination, and the pathological manifestations were Lee's grade and above; 2. TCM is liver kidney yin deficiency syndrome; 3. age 18-70 years old, sex, nationality is not limited; 4. CKD phase 2-4 （89 ml/min\>eGFR（EPI Formula）\>15ml/min/1.73m2）; 5. 24 hour urinary protein≥1g. Exclusion Criteria: 1. It had received immunosuppressive drugs and cytotoxic therapy within the past 3 months more than 4 weeks; 2. It had received corticosteroids (prednisone or prednisolone) within the past 3 months more than 20mg/d for more than up to 4 weeks; 3. Acute or progressive glomerulonephritis patients; 4. Severe complications threat to life, such as severe infection; 5. Active hepatitis B and liver function test sustained abnormal; 6. Patients with malignant tumor or have a history of cancer, HIV infection, history of mental illness, acute central nervous system diseases, severe gastrointestinal diseases, prohibition of the use of hormone; 7. Abnormal glucose metabolism, fasting blood glucose over 6.2mmol/L; 8. Gravid or lactation woman; 9. Other clinical trials are being studied; 10. Merger with other serious disease and dysfunction of the organ.