Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage

Inclusion Criteria: * Subjects ≥ 18 years of age * Aneurysmal subarachnoid hemorrhage, proven on CT angiogram or digital subtraction angiography * Aneurysm treated, either by endovascular embolization or surgical clip ligation * Evidence of increased velocities on transcranial dopplers (TCDs) and/or radiographic evidence of vasospasm as seen on angiogram * Cerebral vasospasm as demonstrated by patient's clinical exam (new focal deficit or change in mental status not attributable to any other cause) Exclusion Criteria: * Recurrent subarachnoid hemorrhage * Untreated ruptured aneurysm, for any reason * Patients who die prior to treatment for aneurysm * Patients who are not able to complete at least 6 months of follow-up * Patients who are admitted already in vasospasm (i.e. a delayed admission) * Creatinine clearance less than 20 ml/min * Women with a positive pregnancy test or who are lactating * Other comorbidity which may adversely affect patient outcome, at the discretion of the principal investigator