Pharmacologic Response and Safety of Inhaled Insulin in Type 1 Diabetes

Inclusion Criteria: * Type 1 diabetes mellitus treated with multiple daily insulin injections or continuous subcutaneous insulin infusion and total daily insulin dose less than 1.2 units/kg/day. * Body mass index 18.0 - 28.0 kg/m2. * Hemoglobin A1c less than or equal to 9%. * Forced vital capacity and forced expiratory volume in one second at least 75% of predicted normal values for race, age, gender and height. * Fasting C-peptide less than 0.3 nmol/L. Exclusion Criteria: * Subjects with any condition possibly affecting drug absorption from the lung, in particular subjects with decreased lung function or subjects taking bronchodilators or subjects who smoke. * Active or chronic pulmonary disease. * Any clinically significant major disorders other than diabetes mellitus. * Decompensated heart failure at any time or angina pectoris within the last 12 months or acute myocardial infarction at any time. * Proliferative retinopathy or severe neuropathy.