Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis

Tejs Ehlers Klug350 enrolled

Overview

Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.

Patients referred to tertiary care centers with acute throat infections are most often treated with antibiotics. However, very little is know concerning the prevalent pathogens in patients with acute throat infections without abscess formation. Evidence suggests that Fusobacterium necrophorum plays an important role in complications of acute tonsillitis (e.g. peritonsillar abscess), but also uncomplicated acute tonsillitis. This study aims to explore the throat microbiology of patients with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis with a special attention to a possible role of Fusobacterium necrophorum.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Acute Tonsillitis Peritonsillar Cellulitis Infectious Mononucleosis

Interventions

Throat swabbingOTHER

Eligibility

Sex: ALLMin age: 15 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients referred to our tertiary care center with acute tonsillitis with or without signs of peritonsillar cellulitis and with or without infectious mononucleosis. 2. Center Score 3 or 4. Exclusion Criteria: 1. Abscess formation. 2. Previous tonsillectomy.

Locations (1)

Aarhus University Hospital

Aarhus, Aarhus, Denmark

Outcomes

Primary Outcomes

Prevalence of Fusobacterium necrophorum in throat swab cultures

Time frame: At acute consultation (day 0)

Secondary Outcomes

Number of participants with recurrent throat infections (questionnaire)

Time frame: Six months after acute consultation

Number of participants without eradication of throat pathogens (throat cultures)

"Throat pathogens": Fusobacterium necrophorum, Beta-hemolytical streptococci, A. hemolyticum

Time frame: 14-28 days after acute consultation

Number of participants with complications of severe acute tonsillitis, peritonsillar cellulitis, and infectious mononucleosis

"Complications": admission, abscess Development, change of antibiotic treatment

Time frame: 14-28 days after acute consultation

Prevalence of anti-Fusobacterium necrophorum antibody Development (two-fold or higher increase in antibody level) (blood samples)

Comparison of the prevalence of antibody Development (two-fold or higher increase in antibody level) between patients with recovery of Fusobacterium necrophorum in throat swabs versus patients without recovery of Fusobacterium necrophorum in throat swabs

Time frame: In acute and convalescent sera (day 0 and 14-28)

Data from ClinicalTrials.gov

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