Dose-Response and Variability of Inhaled Insulin in Type 2 Diabetes

Inclusion Criteria: * Type 2 diabetes mellitus treated with insulin injections at a total daily dose less than 1.2 U/kg/day. * Body mass index 25-40 kg/m2 * Hemoglobin A1c 6.5-9.5% * Forced vital capacity and forced expiratory volume in 1 second at least 75% of predicted normal values. * Fasting c-peptide less than 1 nmol/L Exclusion Criteria: * Any condition possibly affecting drug absorption from the lung, in particular subjects with decreased lung function or subjects taking bronchodilators or subjects who smoke. * Active or chronic pulmonary disease. * Any major disorder other than type 2 diabetes. * Decompensated heart failure or myocardial infarction at any time or angina pectoris within the last 12 months. * Proliferative retinopathy or maculopathy or severe neuropathy.