Oxycodone in Serum After Postoperative Oral Oxycodone in Caesarean Sections Under Spinal Anesthesia

University Hospital, Akershus50 enrolled

Overview

All patients undergoing an elective caesarean section under spinal anesthesia will, according to the hospital routines, receive 10 mg oxycodone slow-release tablet when arriving at our postoperative care unit (PACU). Blood samples will be taken at 0 hour, 1 hour, 2 and 6 hours after administration in order to investigate bioavailability.

After written informed consent, blood samples will be taken before administration, after 1 hour, 2 hours and 6 hours. Need of rescue analgesia (morphine iv) and level of pain, as well as side effects will be registered

Study Type

OBSERVATIONAL

Enrollment

Conditions

Analgesic Adverse Reaction Cesarean Delivery Affecting Newborn

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: Healthy women \> 18 years old, with one healthy fetus scheduled for a elective caesarean section in spinal anesthesia, read and signed informed consent \- Exclusion Criteria: * Known intolerability to oxycodone. Previous use of opioids. Hight \< 150 cm, preconceptual BMI \> 35. ASA \> 2.

Locations (1)

Akershus University Hospital

Nordbyhagen, Akershus, Norway

Outcomes

Primary Outcomes

level of oxycodone in serum

Time frame: 1 hour after administration

level of oxycodone in serum

Time frame: 2 hours after administration

level of oxycodone in serum

Time frame: 6 hours after administration

Secondary Outcomes

level of pain

NRS scale 0-10

Time frame: 0, 1, 2, and 6 hours after administration

Data from ClinicalTrials.gov

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