Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU

Nantes University Hospital69 enrolled

Overview

The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia. In presence of bacterial growth on lung samples, the measure of autofluorescence of white corpuscles could help the clinicians to discriminate bacterial colonization from acute infection.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pneumonia

Interventions

Autofluorescence of white corpuscleOTHER

Measure of auto-fluorescence of white corpuscles cells harvested from tracheal aspirate and/or bronchoalveolar lavages

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hospitalization in intensive care units * Mechanical ventilation * Age \> 18 years * Collection of a lung sample for bacteriological analysis for the suspicion of a first episode of lung infection. Exclusion Criteria: * Refuse to participate

Locations (4)

Blois Hospital

Blois, France

Saint-Brieuc Hospital

Saint-Brieuc, France

Saint-NazaireHospital

Saint-Nazaire, France

Vannes Hospital

Vannes, France

Outcomes

Primary Outcomes

Pneumonia

Diagnosis of pneumonia (Clinical Pulmonary Infection Score \> 6, with assessment of the chest radiography by a blinded investigator)

Time frame: 28 days

Secondary Outcomes

Clinical Pulmonary Infection Score > 6

Time frame: day 3

Acute respiratory distress syndrome

PaO2/FiO2 \< 200 with a PEEP \> 5 (Berlin definition)

Time frame: day 90

Duration of mechanical ventilation

Time frame: day 90

Intensive Care unit Length of stay

Time frame: day 90

Mortality

Time frame: day 90

Data from ClinicalTrials.gov

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