Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome

Centre Hospitalier Universitaire Vaudois60 enrolled

Overview

The investigators aim to assess the respiratory effect of short half-life agents in balanced anesthesia on patients suffering from non-treated or suspected obstructive sleep apnea syndrome (OSA) We will study the impact on OSA of a regimen of remifentanil-desflurane versus a regimen of fentanyl-sevoflurane. Each patient will undergo three respiratory portable polygraphies: the night before the surgery ; the first night following the surgery ; the third night following the surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Sleep Apnea Syndromes Sleep Apnea, Obstructive

Interventions

Fentanyl and sevofluraneDRUG

Remifentanil and desfluraneDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Physical status I - III * Patient scheduled to undergo lower limb orthopedic surgery * Patients known for non-treated obstructive sleep apnea or suspected of having an obstructive sleep apnea Exclusion Criteria: * Patients known for treated obstructive sleep apnea ; * Severe respiratory disease (i.e., chronic obstructive pulmonary disease, asthma, pulmonary fibrosis); * Severe cardiovascular disease * Chronic use of opiates ≥ 30mg/j morphine eq. * Chronic use of benzodiazepine * Inability to consent * Refusal

Locations (1)

CHUV (Centre Hospitalier Universitaire Vaudois)

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Number of apnea and hypopnea events per hour of sleep (Apnea-Hypopnea index) in supine position

Time frame: postoperative night 1