Phase II Trial for the Treatment of Relapsed Osteosarcoma

Inclusion Criteria: * Diagnosis of high grade osteosarcoma recurrence * Resectable or unresectable recurrence disease within 24 months from the initial diagnosis * Pleuro-pulmonary recurrence with more than 2 nodules within 24 months from the initial diagnosis * Unresectable first relapse within 24 months from the initial diagnosis * Resectable or unresectable second of further recurrence of high grade osteosarcoma * Age at diagnosis at least 4years. * Karnofsky performance status over 60%. * Renal function and hepatic In normal limits for age. * L eft ejection ventricular fraction over 50%. * White blood cells over 3000 million/liter and platelets 100000 million/liter * Birth potential female must agreed to contraception * Signed written informed consent Exclusion Criteria: * Contraindication to the use of any study drugs * Mental, social and geographic conditions which fail to ensure adequate adherence to the study * Hepatitis and human immunodeficiency virus active infection * Pregnancy or breast-feeding * Previous treatment with Gemcitabine, Docetaxel and Ifosfamide