Patient-reported Outcomes in Subjects Treated With ReFacto AF Routine Prophylaxis

Inclusion Criteria: 1. Severe (FVIII: C \<1%) or moderately severe (FVIII: C ≥1 - ≤2% with severe phenotype \[at least 4 spontaneous bleeds clinically documented during a 6 months period\] and without inhibitors) male subjects with hemophilia A receiving routine prophylaxis treatment. 2. Age: * From 2 to 18 years; * Subjects above 18 years who began routine prophylaxis treatment in childhood (and were part of the national prophylaxis program when turned 18 years). 3. Previously treated patients (PTPs) with hemophilia A. Previously treated patient (PTP) is considered in this study as a subject who has at least 50 exposure days to any FVIII product. An exposure day (ED) is a 24-hour period during which a dose of FVIII concentrate has been administered, irrespective of size and frequency. 4. No history and no current FVIII inhibitor defined as a titer ≥0.6 BU/mL or any measured Bethesda inhibitor titer greater than the upper limit of normal for the laboratory performing the assay. 5. Subjects who are scheduled by their treating physician to initiate prophylaxis with ReFacto AF or to continue previously initiated prophylaxis with ReFacto AF, and subjects who are switching from prophylaxis with another FVIII product to ReFacto AF. 6. Evidence of a personally signed and dated informed consent and assent (for children 6-17 years of age) document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study. Main Exclusion Criteria: 1. Subject has known hypersensitivity to the active substance or any of the excipients. 2. Subject has known allergic reaction to hamster proteins. 3. Presence of any bleeding disorder in addition to hemophilia A. 4. Treatment with any investigational agent or device within the past 30 days. 5. Any other contraindications according to Summary of Product Characteristics (SPC). 6. Unsuitable to participate in study for any other reason as assessed by the investigator. 7. Subjects (or a legally acceptable representative) not able to understand study documents and study procedure.