The investigators primary objective in this clinical intervention study, therefore, was to explore the impact of omega-3 PUFAs in conjunction with scaling and root planing on salivary markers (in patients with chronic periodontitis.
Thirty systemically healthy subjects with chronic periodontitis were enrolled and randomly allocated into two groups. The control group (n=15) was treated with scaling and root planing (SRP)+placebo whereas the test group (n=15) was treated with SRP and dietary supplementation of low-dose omega-3 PUFAs (6.25 mg EPA and 19.19 mg DHA). Clinical parameters were taken at baseline, 1, 3 and 6 months following therapy. Saliva samples were obtained at the same time intervals and analyzed for tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
placebo drug identical except for the fish oil supplement, were only performed at baseline.
omega-3 PUFAs supplement, were only performed at baseline.
Instrumentation was performed until the root surface was considered smooth and clean, according to the operator's clinical judgement.
change in levels of salivary TNF alpha
Time frame: From baseline to 1, 3, 6 months
change in levels of salivary SOD
Time frame: From baseline to 1, 3, 6 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.