Prevalence of Genetic Polymporphism on RNF213 rs112735431 Gene in Non-cardioemboli Ischemic Cerebrovascular Disease

N/AUnknownNCT02720861

Chulalongkorn University200 enrolled

Overview

To explore the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease in Thai patients.

This is an cross-sectional observational study in Chulalongkorn hospital, to determine the prevalence of genetic polymorphism on RNF213 rs112735431 gene in non-cardioembolic ischemic cerebrovascular disease. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were admitted in Chulalongkorn Hospital for acute ischemic stroke treatment.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Ischemic Stroke

Interventions

DNA sequencingGENETIC

withdraw 3m blood from vein only once during the whole design to analyse on DNA sequencing on RNF213 rs112735431 Gene

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Nationality in Thailand * Age equal or more than 18 years * Clinical and imaging diagnosis of acute ischemic stroke * Patient consent to participate in the research Exclusion Criteria: * High risk for cardioembolic stroke by TOAST classification * Contraindication for venipuncture * Pregnancy or breast feeding patient * History of head and neck radiation * Down's syndrome * Marfan syndrome * Autoimmune disease such as SLE * Ongoing malignancy or remission of malignancy less than 1year

Locations (1)

Suporn Travanichakul

Bangkok, Bangkok, Thailand

RECRUITING

Outcomes

Primary Outcomes

Number of Participants With RNF213 rs112735431 Gene polymorphism

Time frame: 1 year

Central Contacts

Suporn Travanichakul, MD

CONTACT

0858054513 stravanichakul@yahoo.com

Data from ClinicalTrials.gov

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