Graves' Orbitopathy and Hypercholesterolemia

N/ACompletedNCT02721992

University of Pisa250 enrolled

Overview

The investigators have recently observed retrospectively that the occurrence of Graves' Orbitopathy in patients with Graves' disease is less frequent in patients with normal cholesterol levels, in line with another recent observation suggesting that statins play a protective role in Graves' patients from developing Graves' Orbitopathy. The present study is designed in order to investigate the possible association between Graves' Orbitopathy and high cholesterol level as well as the relation between Graves' Orbitopathy degree and high cholesterol level

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Graves' Ophthalmopathy Hypercholesterolemia

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Graves' disease with Graves' Orbitopathy 2. Graves' disease without Graves' Orbitopathy Exclusion Criteria: 1. Previous treatment with radioiodine 2. Previous treatment with thyroidectomy

Locations (1)

Ospedale Cisanello-Endocrinology I and II

Pisa, Italy

Outcomes

Primary Outcomes

Relationship between LDL cholesterol levels and Graves' Orbitopathy

Relationship between the levels of LDL cholesterol and the presence of Graves' Orbitopathy

Time frame: Baseline

Secondary Outcomes

Relationship between LDL cholesterol levels and the activity of Graves' Orbitopathy

Relationship between the levels of LDL cholesterol and the Graves' Orbitopathy clinical activity score

Time frame: Baseline

Relationship between LDL cholesterol levels and the severity of Graves' Orbitopathy

Relationship between the levels of LDL cholesterol the Graves' Orbitopathy severity score (NOSPECS score)

Time frame: Baseline

Data from ClinicalTrials.gov

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