Comparative Study of Two Embryo Culture Systems

Centre Hospitalier Universitaire Dijon388 enrolled

Overview

The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems. Indeed, these two systems, available in only two MAP centres in France, make it possible to maintain a stable temperature and gaseous environment during the in-vitro development of the embryos. It is necessary to observe the development of the embryos to determine which embryos have the highest implantation potential. These observations are done from time to time by microscope for one system and continuously using an incorporated video camera for the other (cinematographic study). The MAP centre in Dijon wishes to compare the interest of these two systems.

Study Type

OBSERVATIONAL

Enrollment

388

Conditions

Infertility

Interventions

EmbryoscopeDEVICE

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Persons who have provided oral consent * Attempt at In Vitro Fertilization with ICSI (IntraCytoplasmic Sperm Injection) * At least 6 mature ovocytes to microinject Exclusion Criteria: * Persons not covered by national health insurance * Attempt at In Vitro Fertilization (IVF) * Fewer than 6 mature ovocytes * Decision to transfer at the zygote stage during the multidisciplinary meeting * Attempts made in a context of viral risk (both systems are in a virus risk-free zone) * Attempts with surgically-harvested spermatozoa

Outcomes

Primary Outcomes

Implantation rate

The implantation rate is defined as the number of embryos implanted (gestational sacs seen on the US scan) compared to the total number of embryos transferred.

Time frame: 16 weeks after transfer

Secondary Outcomes

Rate of miscarriages