To examine antihypertensive effect, pharmacodynamics, and safety of long-term administration of CS-3150 as monotherapy and in combination with calcium channel blocker or renin-angiotensin system inhibitor in patients with essential hypertension.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
368
CS-3150 2.5mg to 5mg, orally, once daily for 28 or 52 weeks
Unnamed facility
Osaka, Japan
change from baseline in sitting systolic and diastolic blood pressure
Time frame: week 0 (baseline) to end of weeks 12, 28, and 52
Change from baseline in 24-hr ambulatory blood pressure monitoring (ABPM)
Time frame: week 0 (baseline) to end of weeks 12, 28, and 52
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