The aim of this study is the identification of complications in diabetes mellitus pediatric patients and to compare the clinical, anthropometric, and biochemical characteristics between children in the different types of diabetes mellitus.
Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin resistance in target tissues. This study identify the influence of pathogenic factors on the evolution of diabetes mellitus and in the presence of chronic complications.
Study Type
OBSERVATIONAL
Enrollment
500
Hospital Regional de Alta Especialidad del Bajío
León, Guanajuato, Mexico
RECRUITINGDiabetic retinopathy
A microvascular complication determined by ophthalmological evaluation
Time frame: year 3
Peripheral diabetic neuropathy
A microvascular complication determined by neurological exam in either foot
Time frame: year 5
Nerve damage
A microvascular complication determined by nerve conduction study in either foot
Time frame: year 5
Microalbuminuria
A microvascular complication determined by urine albumin excretion \>= 30 mg/day
Time frame: annual
Cardiac function
A cardiovascular risk indicator determined by echocardiogram
Time frame: year 5
Cognitive evaluation
Determined by scores on the Mini-Mental State Examination
Time frame: year 3
Intelligence quotient evaluation
Determined by Intelligence quotient test
Time frame: year 3
Body composition
Determined by body mass index (BMI) percentiles computed from physical measurements of height and weight and corresponding percentile tables
Time frame: annual
Glycemic control
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Determined by HbA1c
Time frame: annual
Beta cell function
Determined by fasting C peptide
Time frame: annual
Pancreatic autoimmunity
Determined by pancreas autoantibodies
Time frame: onset of diabetes
Insulin resistance
Determined by insulin sensitivity
Time frame: annual
Alpha cell function
Determined by glucagon
Time frame: year 5
Hyperlipidemia
Determined by lipid profile
Time frame: annual
Hypothyroidism
Determined by thyroid profile
Time frame: annual
Hypertension
Determined by collection of systolic and diastolic blood pressure and calculation of their percentile values
Time frame: annual