Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
100
one time exposure to e-cigarette vapor with nicotine
One time exposure to e-cig without nicotine
one time exposure to empty e-cigarette (sham control)
UCaliforniaLA
Los Angeles, California, United States
Heart Rate variability
Heart rate variability is a measure of autonomic tone
Time frame: 10 minutes after exposure
Paraoxonase
plasma oxidative stress
Time frame: less than 1 hour after exposure
muscle sympathetic nerve activity
Muscle sympathetic nerve activity (MSNA)
Time frame: 10 minutes after exposure
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