Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers

Inclusion Criteria: * Clinical diagnosis of type2 diabetes * Body Mass Index between 27 and 33 kg / cm ² * HbA1c \< 8.5% * Non-pathological Electrocardiogram * Heart rate between 50 and 80 beats per minute at rest. * Complete Blood Count (CBC) with no significant anomaly in terms of the investigator.. * Serum electrolytes without clinically significant abnormalities in terms of the investigator. * Liver function tests without clinically significant abnormalities in terms of the investigator * Renal function tests without clinically significant abnormalities in terms of the investigator * Good peripheral vein (forearm and back of the hand). * Agreement to participate in the establishment of a serum bank. * Ability to sign informed consent. * Affiliation to a social security scheme Exclusion Criteria: * Secondary prevention of cardio-vascular disease * Insulin therapy or Glucagon Like Peptid 1 (GLP-1) analogs therapy in the 6 months before inclusion. * Risk factor, treatment or electrocardiogram as recommended by International Conference on Harmonization (ICH) E14 "Clinical Evaluation of QT / QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs" * Repeated a QTc interval\> 450 ms measurement * Risk factor for torsade de pointes: myocardial infarction, hypokalemia, family history of long QT syndrome * Personal history of cancer. * Positive HIV serology. * Hepatitis B serology positive. * Positive hepatitis C serology. * Cognitive impairment or mental illness (at the discretion of the investigator). * Chronic excessive alcohol consumption (consumption \> 30g/day or 210g/week). * Person under judicial protection, guardianship. * Subject with a resting systolic blood pressure greater than 140 mm Hg and diastolic blood pressure greater than 90 mmHg * Smoking more than 10 cigaret per day and can not be interrupted for 24 hours.