Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.

Poitiers University Hospital20 enrolled

Overview

The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.

Sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (SD) could impact respiratory muscle endurance. A lack of inspiratory endurance could lengthen weaning from invasive ventilation. The purpose of this study is to confirm whether SD alters inspiratory endurance and to identify brain mechanisms involved in SD-induced decreased endurance. A group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. Electrophysiological parameters (EEG, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Sleep Deprivation Healthy Volunteers Diaphragm

Interventions

Sleepless nightBEHAVIORAL

Each subject will undergo 28 hours of sleep deprivation.

Normal sleep nightBEHAVIORAL

Normal sleep at home before trial.

Eligibility

Sex: MALEMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male adult volunteers * Aged 25 to 45 years * Regularly sleeping more than 6 hours per night * Not excessive coffee consumers (\< 3 expressos / day) * Non smokers * Absence of respiratory, cardiac, muscular or neurological disease or diabetes * With a neutral Horne \& Ostberg score Exclusion Criteria: * Previous history of respiratory disease or otorhinolaryngological (asthma, respiratory allergies, swallowing disorders, oropharyngeal malformations) * History of epilepsy or syncope during sleep deprivation * Taking medications that interfere with sleep (antidepressants, benzodiazepines…)

Locations (1)

CHU de Poitiers

Poitiers, France

Outcomes

Primary Outcomes

Time, in minutes, measured from the beginning of the inspiratory endurance test and the end, defined by the patient's wish to stop.

Time frame: The day after one normal night or one sleepless night.

Data from ClinicalTrials.gov

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