Dexamethasone With Super-hydration for Prevention of Postoperative Nausea and Vomiting

Assiut University100 enrolled

Overview

Postoperative nausea and vomiting (PONV) are the most common and distressing side effects following Laparoscopic cholecystectomy

In the operating room, standard monitors included electrocardiogram, noninvasive arterial blood pressure, arterial oxygen saturation, and end-tidal carbon dioxide were connected. All patients received standardized anesthetic technique. At the end of surgery, gastric contents were suctioned via an orogastric tube before extubation. Atropine and neostigmine (1/2.5 mg) was given slowly I.V. to antagonize the residual neuromuscular block. Then, the trachea was extubated. Then, patients were transferred to the post-anesthesia care unit in a stable condition. Patients were allowed to drink liquids as soon as requested.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

100

Conditions

Nausea and Vomiting, Postoperative

Interventions

DexamethasoneDRUG

5 mg I.V. Dexamethasone just before induction

10 ml/kg Ringer's lactateDRUG

Intra-operative 10 ml/kg Ringer's lactate solution .

30 ml/kg Ringer's lactateDRUG

Intra-operative 30 ml/kg Ringer's lactate solution .

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: American Society of Anesthesiologists (ASA) physical status I or II aged Elective laparoscopic cholecystectomy Exclusion Criteria: Steroids use within the last 3 days before surgery Antiemetic use within the last 3 days before surgery Opioids use within the last 3 days before surgery. Patients with liver, cardiac or renal diseases Patients with Pregnancy Patients with Bmi ˃ 30kg/m2 Patients with Delayed wound healing Open surgery

Locations (1)

Faculty of Medicine

Asyut, Asyut Governorate, Egypt

Outcomes

Primary Outcomes

Postoperative Nausea and Vomiting (PONV)

A nurse, who was unaware about the groups to which the patient belonged, evaluated patients at 0, 6, and 24 h after surgery for any symptoms of nausea, retching, or vomiting. PONV is classified as early, if occurring up to 6h after surgery, or late, if occurring between 6 h up to 24 postoperatively. A Verbal Descriptive Scale (VDS), was used to assess the severity of PONV: no PONV (grade 0), mild PONV (grade 1), moderate PONV (grade 2) and severe PONV (grade 3)