The purpose of this study is to assess the effect of a training of the inspiratory muscles against resistance at home during 10 weeks in multiple sclerosis patients with a severe disability.
Patients will be informed about the study procedures during a follow-up consultation or an hospitalization in a Physical and Rehabilitation Medicine Unit. If they give their informed consent to participate in the study, an investigator will randomize them into one of the 2 arms of the study. This study consists of 3 visits. The first visit (inclusion) is planned at day 0, the second visit 10 weeks later and the third 3 months after day 0. A patient who is randomized in the experimental arm will have to follow 10 weeks of rehabilitation of the inspiratory muscles at home between first and second visit. During this period, investigators will call these patients once a week to assess the compliance with the rehabilitation. The patients who have been randomized in the control group will not follow this rehabilitation program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
46
10 minutes 2 times a day : 30 inspirations per session during 10 weeks
Hospital Group of the Catholic Institute of Lille
Lomme, France
Fatigue graded according to EMIF-SEP questionnaire
EMIF-SEP questionnaire (French valid version of the Fatigue Impact Scale, self-administered questionnaire to measure fatigue in multiple sclerosis patients)
Time frame: 3 months
Sleep disorders graded according to the Epworth Sleepiness Scale
Time frame: 3 months
Quality of life graded according to the SEP-59 questionnaire
SEP-59 questionnaire (french validated self-administered questionnaire to assess quality of life in multiple sclerosis patients)
Time frame: 3 months
Maximal inspiratory pressure graded according to the Black and Hyatt method
respiratory manometer according to Black and Hyatt method
Time frame: 3 months
Maximal expiratory pressure graded according to Black and Hyatt method
respiratory manometer according to Black and Hyatt method
Time frame: 3 months
Forced vital capacity (FVC) graded with a portable spirometer
Time frame: 3 months
Tidal volume graded with a portable spirometer
Time frame: 3 months
Forced expiratory volume in one second (FEV1) graded with a portable spirometer
Time frame: 3 months
FEV1/ FVC ratio graded with a portable spirometer
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Time frame: 3 months
Energy consumption during repeated effort
Metamax 3B
Time frame: 3 months
Depression graded according to the French version of the Beck Depression Inventory Fast-Screen
French version of the Beck Depression Inventory Fast-Screen, validated scale in multiple sclerosis
Time frame: 3 months
Swallowing problems graded according to the DYMUS score
Time frame: 3 months
Level of disability graded by the EDSS (Expanded Disability Status Scale)
These functional parameters will enable the assessment of the level of disability by a clinical examination
Time frame: 3 months
Collection of the drug treatments received evaluated by a questionnaire
Time frame: 3 months