This study evaluates the feasibility of laparoscopic surgery in patients diagnosed with colorectal liver metastases. Half of participants will be operated on by laparoscopic approach and the results obtained will be compared with the results from the other half of patients operated on by open approach.
The safety and efficacy of liver surgery in the treatment of colorectal liver metastases are well established for the open approach. It allows good results in terms of complications, disease free survival and overall survival, and for these reasons it has become the gold standard technique in the treatment of colorectal liver metastases. On the contrary, the role of laparoscopic liver resection in this context is not so clear nowadays. Generally, laparoscopic surgery offers some advantages such as less pain, shorter hospital stay and better aesthetic results. But the use of laparoscopic approach in liver surgery is still discussing: two international consensus conferences have been held and no strong conclusions have been made. Furthermore for colorectal liver metastases no randomized trials, comparing both techniques, have been published until now. To assess the feasibility of laparoscopic liver resection for colorectal metastases, the investigators propose this trial in which the patients suitable for laparoscopic approach are randomized to open or laparoscopic group
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
The investigators perform an anatomical liver resections or wedge resections depending on tumour's location and tumour's characteristics
Hospital Universitario "Virgen de la Arrixaca"
Murcia, Spain
Overall survival
Time frame: 1 year
Surgical operative time
Duration of the surgical intervention
Time frame: Intraoperative
Blood losses
Blood loss in milliliter
Time frame: Intraoperative
Transfusion
Number of blood transfusions required during surgical operation
Time frame: Intraoperative
Hospital stay
Days between surgical operation and hospital discharge
Time frame: Up to 3 months
Time between surgery and adjuvant chemotherapy
Days between surgical operation and the beginning of adjuvant chemotherapy
Time frame: Up to 3 months
Mortality
Time frame: 90 days
Morbidity
Time frame: 90 days
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