Closing the Loop in Adults With Type 1 Diabetes and HbA1C<7.5% Under Free Living Conditions

Inclusion Criteria: * The subject has type 1 diabetes as defined by WHO * The subject is 18 years of age or older * The subject will have been on an insulin pump for at least 6 months with good knowledge of insulin self-adjustment including carbohydrate counting * The subject is treated with one of the rapid acting insulin analogues (Insulin Aspart, Insulin Lispro or Insulin Glulisine) * HbA1c \<7.5% (58mmol/mmol) based on analysis from central laboratory or equivalent * The subject is willing to perform regular finger-prick blood glucose monitoring, with at least 6 measurements per day * The subject is willing to wear closed-loop system at home and at work place * The subject is willing to follow study specific instructions * The subject is willing to upload pump and CGM data at regular intervals * Female subjects of child bearing age should be on effective contraception and must have a negative urine-HCG pregnancy test at screening. Exclusion Criteria: * Non-type 1 diabetes mellitus * Any other physical or psychological disease or condition likely to interfere with the normal conduct of the study and interpretation of the study results * Current treatment with drugs known to have significant interference with glucose metabolism, such as systemic corticosteroids, as judged by the investigator * Known or suspected allergy against insulin * Subjects with clinically significant nephropathy, neuropathy or proliferative retinopathy as judged by the investigator * Significantly reduced hypoglycaemia awareness as judged by the investigator * More than one episode of severe hypoglycaemia as defined by American Diabetes Association in preceding 6 months (Severe hypoglycaemia is defined as an event requiring assistance of another person to actively administer carbohydrates, glucagon, or take other corrective actions). * Random C-peptide \> 100pmol/l with concomitant plasma glucose \>4 mM(72 mg/dl) Total daily insulin dose \> 2 IU/kg/day * Subject is pregnant or breast feeding or planning pregnancy in near future (within next 3 months) * Severe visual impairment * Severe hearing impairment * Subjects using implanted internal pacemaker * Lack of reliable telephone facility for contact * Subject not proficient in English (UK) or German (Austria) * Subjects who are living alone * Additional exclusion criteria specific for Austria: Positive results on urine drug screen (amphetamines/metamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates). * Additional exclusion criteria specific for Austria:Positive alcohol breath test.