The purpose of this study is to determine whether colorectal cancer diagnosed by screening (primary screening colonoscopy, colonoscopy after immunochemical based faecal occult blood test) has more favourable clinical-pathological characteristics than colorectal cancer diagnosed for symptoms. We aimed to compare these two groups of patients at the time of diagnosis and confirm the efficiency of the screening programme.
Multicentre prospective observational study. 12 centres across the Czech rep. included. Study approved by Ethical Committee. All participants gave their informed signed consent. Each centre was assigned a unique ID number to distinguish between the locations in which patients were enrolled. Patients informations were stored under identification number in secure internet database (RedCap) run by The International Clinical Research Center of St. Anne's University Hospital Brno.REDCap is a secure, web-based application designed to support data capture for research studies. Statistical analysis was done with SAS, ver. 9.3. Descriptive statistics such as absolute and relative frequencies and median with 95 % confidence intervals were used. Differences between the screening and non-screening groups were compared using the Chi-square test or Fisher's exact test (categorical parameters) and Mann-Whitney test (continuous parameters). Results with a p-value \< 0.05 were considered statistically significant
Study Type
OBSERVATIONAL
Enrollment
276
Institute for Clinical and Experimental Medicine
Prague, Czechia
Colorectal Cancer Stage (pTNM)
Differences between colorectal cancer stage (0,I,II) in screening vs. non-screening group. * 0\. stage (Tis N0 M0) * I. stage (T1-2 N0 M0) * II. stage (T3-4 N0 M0) * III. stage (T1-4 N1-2 M0) * IV. stage (T1-4 N1-2 M1) Stages 0,I II were considered to have better outcome
Time frame: at time of diagnosis
Colorectal Cancer Grade
Differences between colorectal cancer grade in screening vs. non-screening group. * GX (cannot be identified) * G1 (well diff.) * G2 (moderately diff.) * G3 (poorly diff.) * G4 (undifferentiated) Grades 1,2 were considered to have connection with lower stage
Time frame: after surgery was performed
Colorectal Cancer Resection Margins
Difference between colorectal cancer resection margins (RX, R0, R1, R2) in screening vs. non-screening group. * RX: cannot be identified * R0: no cancer cells seen microscopically at the resection margin * R1: cancer cells present microscopically at the resection margin (microscopic positive margin) * R2: gross examination by the naked eye shows tumor tissue present at the resection margin (macroscopic positive margin)
Time frame: after surgery was performed
Colorectal Cancer Metastasis
Differences between occurrence of colorectal cancer metastasis (MX, M0, M1) between screening vs. non-screening group. * MX: cannot be measured * M0: cancer has not spread to other parts of the body * M1: cancer has spread to other parts of the body
Time frame: at time of diagnosis
Colorectal Cancer Surgery
Median time between diagnosis and surgery.
Time frame: time between diagnosis and surgery, measured after surgery was performed
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Colorectal Cancer and Palliative Therapy
Differences between neoadjuvant, adjuvant and systemic palliative therapy in screening vs. non-screening group. Number of patients treated with palliative therapy in both groups.
Time frame: during treatment plan setting