Comparison of Treatment of Recurrent HCC With Repeat Hepatectomy,and TACE With AFP Conversion

Eastern Hepatobiliary Surgery Hospital150 enrolled

Overview

The purpose of this study is to compare the treatment of recurrent hepatocellular carcinoma with repeat hepatectomy,and transcatheter arterial chemoembolization (TACE) with AFP conversion.

Though many HCC patients have been benefited from hepatectomy treatment, still the high recurrence rate after the hepatectomy led to limited effectiveness. This is the first study in same case system on comparison of effectiveness among repeat hepatectomy, and TACE with AFP conversion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

150

Conditions

Recurrent Hepatocellular Carcinoma

Interventions

TACEPROCEDURE

In this study we prospectively select some early diagnosed recurrent HCC patients after radical resection with AFP conversion, then they will be treated with transcatheter arterial chemoembolization (TACE)

HepatectomyPROCEDURE

Repeat Hepatectomy after postoperation recurrence

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. via clinical diagnosis and confirm it is early recurrent liver cancer with AFP conversion, and not accept any anticancer treatment. 2. age:18-70years 3. better liver function (Child-Pugh，class A or B) Exclusion Criteria: 1. reject to attend； 2. impossible to come to our hospital for physical examination regularly. 3. cancer epitome、seed focus、lymph node or distant metastasis 4. Blood clotting function hindrance; 5. serious heart、lung、kidney disease

Locations (1)

Eastern hepatobilliary surgery hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

overall survival

Time frame: 3 years

Data from ClinicalTrials.gov

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