MRI Assessment of Patient Suitability for Cardiac Resynchronization Therapy (CRT)

NYU Langone Health110 enrolled

Overview

The goals of this project are to: 1) explore the potential use of magnetic resonance imaging (MRI) data for improved prediction of response to cardiac resynchronization (CRT), and 2) use the MRI-derived data together with a computer model of the cardiovascular system to study the relative roles of different factors in the mechanical effects of dyssynchrony in failure, and in the response (or lack thereof) to CRT.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

110

Conditions

Cardiac Resynchronization Therapy Magnetic Resonance Imaging (MRI)

Interventions

Cardiac MRIPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female patients ages 18 and over scheduled by conventional criteria (symptomatic impairment of cardiac function with broadened QRS) for clinical CRT procedures at NYULMC. * Normal kidney function as determined by GFR levels. Inclusion Criteria for Controls * Normal kidney function as determined by GFR levels * No significant cardiovascular disease or risk factors. Exclusion Criteria: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing (which will be removed) * pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest.

Locations (1)

New York University School of Medicine

New York, New York, United States

Outcomes

Primary Outcomes

Derivation of score of patient suitability for CRT

Binary logistic regression and receiver operating characteristic curve (ROC) analyses will be used to assess the utility of baseline (pre-CRT) MRI-derived measures, alone and in combination, for the prediction of response to CRT.

Time frame: 4 Years

Data from ClinicalTrials.gov

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