Effects of Gonadotropin Replacement Therapy on Metabolic Parameters in Patients With Hypogonadism

Gulhane School of Medicine30 enrolled

Overview

Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism

30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Idiopathic Hypogonadotropic Hypogonadism

Interventions

human chorionic gonadotropin, human menopausal gonadotropinDRUG

drug for the treatment of male hypogonadism

Eligibility

Sex: MALEMin age: 22 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Serum testosterone concentration \< 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, - Exclusion Criteria: diabetes mellitus, arterial hypertension other hormone deficiencies \-

Outcomes

Primary Outcomes

oxidative stress after hCG and HMG treatment

Time frame: 2010-2012

HDL levels after hCG treatment

Time frame: 2010-2012

total cholesterole levels after hCG treatment

Time frame: 2010-2012

Data from ClinicalTrials.gov

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