Functional Urodynamic Changes in Chronic Kidney Disease Patients and Does Insertion of Urinary Catheter Delay the Need for Kidney Dialysis

Assaf Harofeh MC100 enrolled

Overview

The aim of the investigators work is to describe the urodynamic results in the CKD (chronic kidney disease) grade 4 patients and to verify observations that urinary catheter may improve kidney function in those patients. 100 patients with CKD grade 4 will do urodynamic examination. All patients will be randomized into two groups / the intervention group that will be inserted urinary catheter for 2 weeks and the follow up group. Kidney function will be monitored by creatinin values and the investigators will measure the time to dialysis in the two groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Renal Insufficiency, Chronic

Interventions

urinary catheter

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 * chronic kidney disease grade 4-5 (eGFR (estimated glomerular filtration rate) \<30) * eligible to sign a consent form Exclusion Criteria: * non controlled Diabetes Melitus (HbA1C\>10%) * not controlled HTN (Hypertension) * cardiovascular event requiring cardiac stenting * renal hydronephrosis or post void rest \> 200CC according to US (Ultrasound) * acute renal failure * not eligible for urodynamics for any reason * constant urinary catheter for any reason

Outcomes

Primary Outcomes

kidney function change

measured by creatinine values mg/dL

Time frame: At the time of urinary catheter insertion. Two weeks from the insertion and than after 8,16, 24, 32, 40 and 48 weeks after the urinary catheter insertion. (at total 52 weeks of follow up)

Secondary Outcomes

time to dialysis

Time frame: at least 1 year from the time of catheter insertion