Intrathecal Morphine for Postoperative Analgesia Following Laparoscopic Bariatric Surgery

Assiut University100 enrolled

Overview

this study compares the use of intrathecal morphine, to multimodal analgesic techniques for postoperative pain management following laparoscopic bariatric surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

100

Conditions

Postoperative Pain

Interventions

intrathecal morphineDRUG

received 0.3mg morphine (0.3ml) added to 1.2ml of bupivacaine 0.5% (total volume 1.5ml), intrathecally, immediately before induction of general anesthesia.

intrathecal salineDRUG

received 0.3ml saline added to 1.2mlof bupivacaine 0.5% (total volume 1.5ml), intrathecally, immediately before induction of general anesthesia.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesia (ASA) II-III patients. * Aged 30-50 years. * The body mass index (BMI) of the patients needed to be over 40 kg/m² or over 35 kg/m² with at least one comorbidity. Exclusion Criteria: * Patients with a known allergy to the study drugs. * Advanced cardiac, respiratory, renal or hepatic disease. * Coagulation disorders. * Infection at or near the site of intrathecal injection. * Drug or alcohol abuse. * Psychiatric illnesses that may interfere with perception and assessment of pain.

Outcomes

Primary Outcomes

Total postoperative analgesic consumption.

the efficacy of the studied dose of intrathecal morphine in reducing postoperative analgesic consumption.

Time frame: 24 hours postoperative

Secondary Outcomes

Visual analogue scale (VAS) scores

postoperative pain scores

Time frame: 24 hours postoperative

Time to first request of rescue analgesia.

Time frame: 24 hours postoperative

Tolerability as assessed by the incidence of side effects

the incidence of side effects

Time frame: 24 hours postoperative

Data from ClinicalTrials.gov

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